[tdido]

Actually, for the use case of genome assemblies you can compensate for the error rate with depth of coverage. Long reads are already the state-of-the-art for assembling genomes and are allowing us to get information that is simply invisible using short reads.

https://www.biorxiv.org/content/10.1101/2021.05.26.445798v1

[londons_explore]

One would think a hybrid approach will bring the best results...?

Long reads help with alignment and arrangement, and short reads eliminate small errors of just a few base pairs.

[f6v]

It's definitely getting better, but errors have to be corrected computationally, and it still seems like a big challenge.