[thorin1]

I had a similar problem and couldn't use keyboard/mouse for a week when it reached the tipping point.

Definitely start with the ergonomics of your workspace.

This solved my issues:

1. Use trackball instead of a mouse - Logitech M570 is amazing.

2. Use wrist support or a really slim keyboard like the Apple Magic keyboard. Your wrists should not be bent.

3. Use keyboard without numerical keys at the right. Reaching too much to the right to use the mouse was also causing me the issues.

Also don't forget about ergonomics of your desk, chair, and display.