[marcinzm]

>By that I mean encrypted communication on all computer buses (including USB, HDMI)

That only delays things since in the end you still need a human being to be able to play. So you can have a camera looking at the screen and a mouse/keyboard with some wires soldered to the key points.

[runnerup]

Indeed. Or a robot arm moving the mouse. The analog hole will always exist. However, it may prove hard to make a computer move the mouse like a human, and type like a human. Heuristics will likely be able to separate human from bot input for quite awhile still.

The game makers probably enjoy a large advantage in size-of-dataset vs cheat makers.