[pyuser583]

> Thalidomide had no negative effects on non-human animals, but created notoriously deformed children in humans.

Thalidomide was never approved for treating in nausea in pregnant women in the US. It was prescribed off label, but the FDA rejected it for that purpose.

Why did the FDA reject it if animal tests didn’t show deformities?

To be clear, that’s not a rhetorical question. I’ve heard rumors the FDA wasn’t convinced thalidomide would be effective - which is very different from worries over fetal abnormalities.

Do you know the background there?