[axguscbklp]

I think that the native Americans would have managed to learn how to use European technology just fine, but I think that it would have been hard for them to build the necessary infrastructure to mass-produce it in time. Maybe if they had managed to ally with one group of Europeans long enough to hold the others off and give them the needed time, it would have worked.

[SuoDuanDao]

I doubt that, because of the disease factor. From what I remember of my high school history classes, the English and French were fairly closely matched in strength and fought each other for control of North America. The French did try to ally with the Huron confederacy, while the English traded with the natives but didn't get into serious negotiations until later. Their Alliance didn't help the Franco-Huron faction much, and though it wasn't mentioned I imagine that one factor would have been that pox can spread to one's allies more easily than people one is wary of.

Now, had Europeans had a germ theory of disease by then, maybe that dynamic could have turned out different...

[nradov]

At the time European technology wasn't mass produced either. Technological artifacts were still hand made one at a time by artisans.

[PicassoCTs]

Not really true. https://en.wikipedia.org/wiki/Mercantilism#History

There were lots of artisans, but mercantilism the early stages already had state-run factories for cannons and other "central" managed technology.