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by peter422 1814 days ago
There are 4 tiny RCTs with split results.

There is one medium sized almost randomized trial that shows a strong result. I'm not interested in small retrospective studies. There are 50 retrospective studies that show HCQ is an amazing drug against covid.

Clearly since there is little downside to given vitamin D to people who have low levels, it can and probably should be done, but that is very far from proving that it is a "potent inhibitor" of covid. There also is a clear bias for the person who makes that site since they also want it to be true. Maybe they don't look as hard for studies which disprove what they want. It isn't an overwhelming case.

There is more than enough evidence for a big RCT to actually confirm, but given the safety considerations and low expense it probably makes more sense to just dose everybody and hope it works. But I don't see how you could make grand claims with this evidence.

1 comments

Super-strange to be OK with an EUA for vaccines containing all sorts of new technologies, then quibble the evidence against vitamin D, a naturally occurring drug that we've known for many years is a potent inhibitor of ALL respiratory illness, as well as others: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756814/

Super, super strange that we'd take less-than-typical studies of novel vaccines, and then quibble the evidence on something created by nature that we know is easy to get, easy to dose, very safe, etc.

It's like someone wants to make some profit or something.

So would you encourage people not get vaccinated and just take vitamin D?

Do you believe the evidence for their effectiveness is equal?

I'm not a doctor so I wouldn't encourage anybody to do anything in terms of medical advice. What I would encourage people to do is to think for themselves and review all available evidence before taking any kind of medical treatment, and particularly treatments that have not completed Phase 3 FDA trials.

The evidence about coronavirus is quite, quite clear. There may be long-term severe effects of covid, just like there may be severe deleterious long-term consequences of the vaccines. So you must calculate your risk-benefit ratio and use that to elect whether to take the vaccines or not. For those that are worried about experimental vaccines, I absolutely encourage them to get more fresh air and sunlight--in fact, almost everyone would benefit in many ways from getting outside in the sun, getting fitter, and avoiding prolonged "lock downs" in their houses. (To boot, covid has never been observed in the scientific literature to be transmissible outdoors.)

Here's a peer-reviewed study from the Lancet from this month that shows just how short-term irrelevant covid is to those under age 40 who are reasonably healthy: https://www.thelancet.com/journals/landia/article/PIIS2213-8...

For those under the age of 60, obesity is far and away the thing that makes covid dangerous, and if you're under age 40 and are not obese, the death rate is too low to be measured.

So from that, it seems clear to me: If you're under age 60, get fit (I already am, and getting fitter and fitter every day, which is oddly something never mentioned by the higher-ups at CDC or Pfizer or wherever, which is curious, wouldn't you say?). Get outside.

Effectiveness of the vaccine is irrelevant to me personally because for all people like me covid has thus far posed a risk profile similar to that of driving. Novel vaccine technology presents a totally unknown level of risk, and we've already observed plenty of healthy, young people get all sorts of negative outcomes from it. Plus, again, totally unknown long-term safety profile.

I'm curious why you're so against any kind of solution for covid that doesn't involve novel vaccines.

Name a single vaccine in history that has the type of hidden long term side effect you are worried about. Hidden and long term defined as something that happened only after 6 months from taking the vaccine and is significant.
Are you kidding? Narcolepsy epidemic caused by swine flu vaccine in UK and Northern Europe in 2009/2010.

https://www.narcolepsy.org.uk/resources/pandemrix-narcolepsy

In fact, there are many, many vaccine-related long-term injuries that are well-studied and were totally not detected until well after the fact.

In fact, there's an entire medical school textbook about it, if you want to really know, published by Wiley, called Vacines and Autommunity: https://www.amazon.com/Vaccines-Autoimmunity-Yehuda-Shoenfel...

The corporate press does everything possible to make it seem to the common person that vaccines are the very single medical technology that has zero side-effects and zero long-term safety issues, but that couldn't be further from the truth.

(Wiley is not some crazy conspiracy theory crap, they make legitimate textbooks for colleges everywhere.)

Not to mention, the question itself is biased. You should really ask, Is there any example of an entirely new medical technology (really, three, if you consider the LNP) which post-deployment caused long-term safety issues?

And that would be a resounding yes.

And, please again note, even knowing all I do about all those things and the dangers of vaccines, I still am more vaccinated than you, having taken, e.g., rabies vaccine, even knowing the not-insignificant risks involved.

However, there was a risk I'd catch and be injured by rabies.

There's almost zero risk I'll be injured by covid, lol.

I mean, as well, look at the injuries being caused by the vaccines: They happen to people like me, young and healthy. Covid only hurts the fat people my age. Why would I take the side of the risk that hurts people like me?

I did not say show me a vaccine with unexpected side effects… there are many examples of that.

I said show me one where the onset is hidden until after 6 months. The narcolepsy link above was concentrated in the first 6 months after the shot. At least try me with the dengue vaccine and ADE so I could explain why that is different.

Hundreds of millions of people have taken the vaccines and we know with huge amounts of power the side effects and their (incredibly tiny) probabilities. It is beyond uncommon for a hidden side effect to only appear later, especially with something like a vaccine. It produces an antibody response and goes away. If that antibody response is going to cause problems it generally happens sooner than later when there are the most antibodies.

I, like you, didn’t want to be the first person to take the vaccine. But at this point the safety record shows it is one of the safest, if not the safest, vaccine ever produced. Hopefully you don’t get COVID in the meantime of this point becoming clear to you.