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by rolph
1816 days ago
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efficacy is similar due to conservation of the receptor binding domain[RBD] of spike protien[S] the RBDab is billed as the gold standard neutralizing antibody as when it binds to RBD of the S protien, that particular S protien is no longer able to bind to its ligand [ACE2] should we see a variant that escapes this RBD Antibody mechanism then there will be a possibility of escape, and concommitant requirement to tweak the vaccine antigen. |
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