[jonmc12]

The book, "The Switch" (Clement) is a nice synthesis of recent research on metabolic health. It presents a case that managing metabolic state can mitigate most of the risk of cardio-vascular disease, cancer and mitochondrial damage. Concretely, the book suggests: 1) keep insulin and IGF low through diet, 2) eat a 4:1 or lower ratio of omega-6 to omega-3 fats (to keep cell walls permeable), 3) do a fasting mimicking diet (FMD) every couple of months to trigger autophagy for cellular cleanup.

You can google FMD - the idea is to induce autophagy. This can be measured during the diet with some efficacy by measuring your glucose-ketone index. In theory, the body has the tools to clean and repair cells, including mitochondrial damage, through autophagy.

In addition to FMD, there are a number of autophagy supplements being tested following the 2016 discovery of the role of the cellular mTor switch. To me, the safety and science behind Spermidine is quite compelling. NAD+ plus precursors are compelling. Rapamycin, Metformin and other solutions that target the mTor pathway are also gaining funding and beginning more experiments.

Ketosis is important to the formula. Juv Labs recently introduced a di-ester exogenous ketone that is intended to promote ketogenesis in the liver, and produce endogenous ketones as well. Eating lower glycemic index foods (ie, down-regulate insulin) for a couple days while taking these supplements is a nice way to experiment with how your body adjusts to a ketogenic state. On the other hand, mono-ester exogenous ketones are more for exercise performance.

Lastly, the Bulletproof podcast is a surprisingly consistent (and understandable) source of biohacking and longevity information and discussion. Check out the recent discussion about NAD+ as an example. Rhonda Patrick's Found My Fitness is also an amazing resource.

[agumonkey]

Very nice