[analyte123]

Agreed on missing this facet of their advisory. However, the concentration of ivermectin in the early in vitro study was 35x higher than the plasma concentration reached for the approved ivermectin dose [1] whereas the doses used in ivermectin trials (https://ivmmeta.com) range from 1x to 10x the approved dose daily, with successful results as low as 4x approved dose (1x approved dose daily for 4 days)[2]. So whatever ivermectin is doing, it doesn’t seem to require the concentration that the initial in vitro study required.

[1] https://pubmed.ncbi.nlm.nih.gov/32378737/

[2] The approved dose is actually 200 mcg/kg. I used 12mg to correspond to a normal adult “approved dose” for these numbers.

[joe_the_user]

You've gone from "no, the EMA didn't really to object" to "here's why their objection is wrong". See how that works?

The thing about Covid is that it isn't "super deadly". It has about a 1% fatality rate. That's terrible for society as a whole when the disease is also extremely infectious. But it means that "I took X and recovered from Covid" isn't the most amazing thing.

"So whatever ivermectin is doing, it doesn’t seem to require the concentration that the initial in vitro study required." Maybe the trial dose does nothing at all and people are recovering like they normally do.

[analyte123]

This part of their objection was based on an assumption that doesn’t seem to be as bad as they thought. The trials are controlled to varying degrees of quality.