[mattmcknight]

> Years and years of widespread clinical practice would be my standard

How do you get "years and years of widespread clinical practice" if no one will let people try it?

[rscho]

The point of research is to have a controlled experiment. Not a bunch of individuals taking whatever they like on their own.

[mattmcknight]

Research is not "years and years of clinical practice". Do you agree that "years and years of clinical practice" is not a good criteria to use for prescription, or are you just saying you don't use anything until other people have been using it for years and years. (and in this case, hasn't it been used for years and years?)

[rscho]

I don't use anything not covered by guidelines if I can avoid it. And in the event I can't avoid it, I'll always go for the more usual practice, i.e. the one backed by years and years of experience. If you want to participate in clinical trials, that's another matter entirely and has nothing to do with usual care or individuals taking whatever on their own.

I think that much was pretty clear already.