[staticassertion]

I'm not planning to take metformin but it was discovered a century ago and has been in use for half that time. A quick look shows me that it's the 4th most prescribed medication in the US. I find it hard to understand how this would not satisfy "years and years of widespread clinical practice", at least with regards to understanding negative implications.

But as you said, you can do your own research, so I'll leave things where they stand. You just sound more like someone who's annoyed by pop-science more than someone who actually has strong opinions about the article or Metformin.

[rscho]

I am well aware of the downsides of metformin since someone ends up in my ER (and sometimes dies) because of it most weeks. So you'll excuse me if an off-label and very new potential indication is not an immediate go for me. When we want to open a new indication for a particular drug, evaluation of the risk-benefit ratio for this particular indication has to be performed. There are many factors at play and results are completely unpredictable.

As for the rest no, I'm all for pop-science because it's what stimulates the interest of the masses. The problem in my eyes is more that academic medical studies available to the wider public are akin to a very sharp saw, and people will get cut if they don't know what they're doing.

[staticassertion]

Yeah I'd recommend you open up with information like that in the future, just right off the bat. It's a lot more interesting and at least somewhat useful.