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by mlyle 1836 days ago
Canada/the UK have been doing that.

Odds are it does make things more effective rather than less, based on our experience with other vaccines. But IMO it's not wise, because it wasn't studied.

Still, 2 huge peaks separated by 3-4 weeks provokes really big immune responses.
1 comments
BeefWellington 1836 days ago
> Odds are it does make things more effective rather than less, based on our experience with other vaccines. But IMO it's not wise, because it wasn't studied.

It has since been studied[1] (preprint) and that was exactly what was found -- delaying the second dose provoked a stronger response, similar to many other vaccines.

[1] https://www.birmingham.ac.uk/news/latest/2021/05/covid-pfize...

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mlyle 1836 days ago
Sure, so far preliminary data looks OK. I still don't think it was a wonderful roll of the dice-- it didn't lower susceptibility so much in the short term (because a single dose's efficacy is limited, especially in the old) and it could have made things much worse.
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