[leephillips]

I agree if you have in mind fonts with really thin serifs, such as the classic Computer Modern. But serif fonts in general seem fine to me at 300 dpi, or even 240 dpi. Readability depends more on the particular font used at a particular size, rather than whether it’s serif or not.

[inamiyar]

Yeah the serif/sans distinction is definitely down the list compared to font size, column width, line spacing, contrast, etc. I just brought it up because I consider it part of the "LaTeX" style. But you're right...something something premature optimization