[Miraste]

There are a lot of differences, some of which cause more discomfort than others. Color and contrast are two smaller ones; VR headsets aren't HDR yet and it really shows when trying for realism.

There is also focal length, which is fixed (generally at 2 meters) in VR and creates discomfort, especially when reading. Facebook has eye tracking and motorized varifocal lenses to deal with this, but they're too big and loud and they haven't been able to put them in commercial headsets.