[nick__m]

Yes, the dose makes the poison and yes medicl amphetamines are sometimes abused but the literature you cited¹ isn't really about the medical use of amphetamines. Those papers are about the abuse of amphetamines.

From my experience with Vyvanse I find that amphetamines have a dose response function with linear and exponential steps. 15mg is barely perceptible, 30mg is like a coffee without the anxiety but it last 8 hours. 45mg is like 30mg but a little longer. 60mg in 2 doses (first pill at 7am and next one at 9am) is a perfect treatment against my ADD. Once I tried 90mg and it was terrible, I experienced bruxism, anxiety and hyperacidity for 18 hours. I am sure that I would develop the problems you listed if I were to take 90mg a day but 90mg of Vyvanse is supratherapeutic...

1: Link 41 is about abuse (supratherapeutic and frequent doses). Link 43 I can't comment as I don't have acces but it's an old paper from 1988... Link 45 is about abuse again. Link 46 is about accidental ingestion by a baby. (a therapeutic dose for a teenager is clearly supratherapeutic in a 8months infant) Link 47 is probably about abuse (the abstract talk of reversible consequences of dose escalation) but I don't have acces to the paper.

[nszceta]

You can't avoid capillary vasoconstriction at any dose and that's what makes your teeth rot and gums go bad. Nothing you can do about that. I've used Adderall and Vyvanse many many years ago for "ADHD" as well. Bad breath and increased gum issues made me stop well before any damage occurred.