[faeyanpiraat]

You need to change every old cell in your body to a young version of the cell every once in a while.

The difficult part is the neurons, you need to change them one by one, and restore all their connections, and internal parameters.

This is my theory on how you can “refresh” yourself while keeping you you.

[adflux]

To which extent does the brain not repair neurons already?

[KronisLV]

In regards to the physical changes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596698/

> It has been widely found that the volume of the brain and/or its weight declines with age at a rate of around 5% per decade after age 401 with the actual rate of decline possibly increasing with age particularly over age 70.

I feel like that's probably a big one without getting into the functional changes.

And just adding a bunch of neurons would probably be like giving your computer a new HDD. I think that the argument is about how it's important to preserve the information contained within the old neurons somehow.