[IAmGraydon]

I played out live for a decade and absolutely used the knobs on my pedals live. Most musicians I knew with a pedalboard did the same.

That said, if you use a preset based effects setup like rackmount gear, I could see how this would be cool.

[FrankyFire]

Yeah, true. But you would only change it between songs, I guess, and only to the values you always use for that song, right? - This is what I would capture and use as a preset, preset change triggered by MIDI from the MultiFX unit.

I know some who change their settings during playing, but I wouldn't consider this as standard. Also, you can still add a real Pedal to a MultiFX Board if you really want to change its settings live. On the contrary, automatically changing the settings controlled by your DAW and triggered via MIDI into your MultiFX unit is also pretty common. You don't have to hassle with your Effects at all and can concentrate on playing, what you should, as you need to be absolutely on point.