[entee]

My biggest worry with this would be the low level of off target edits and the number of recombination events that yielded an unwelcome product. Looks like those were very low, but with an N of 4, hard to know long term. The reason being that when you screw around with DNA you can get cancer. This has been an issue in a variety of cases with gene therapy, though is clearly getting much better. This is really cool though, exciting times!

[carbocation]

For what it's worth, unlike earlier CRISPR technology which made DSBs at desired locations, base editing does not make double strand breaks. This is described pretty well, I think, in the journal manuscript[1].

1 = https://www.nature.com/articles/s41586-021-03534-y