No. Wipr is a clean content blocker. I don’t know how it handles auto-updates of the blocklist, but I definitely don’t need to keep the app open nor does it add buttons to the interface like AdGuard does.
Running the app is not mandatory and neither is adding buttons to the interface. If you just need content blockers, you can simply enable just them, close the app and forget about it until you feel the need to check filters updates.