[throwaway197812]

You make good points, but I think my overall point stands: Even a $1000 genome does not provide $1000 worth of value to a healthy individual today. So there is no point in trying to make WGS broadly available, nor is there any justification for insurance companies to cover it. It would be nothing more than a form of luxury "scientific entertainment" a la 23andMe.

Also, I would challenge your suggestion that "The expansive definition of 'sequencing cost' to envelope downstream analysis and storage here is also a mistake." I would argue that it's the opposite: delivering valid and useful sequencing results to a broad population would require even more resources directed toward analyzing the results and also interpreting them for the patients.