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by sradman
1873 days ago
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From 2014, Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein [1]: > Such furin-mediated activation is unusual in that it occurs in part during virus entry. Our findings may explain the polytropic nature, pathogenicity, and life cycle of this zoonotic coronavirus. MERS-CoV uses furin cleavage of S1/S2 but it does not bind to ACE2 like SARS-CoV-2. [1] https://www.pnas.org/content/111/42/15214 |
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