[jacobolus]

The first-order difference seems to be: Plot looks designed to be quicker to learn and take less syntax when you want to throw something generic up quickly, with an API carefully designed to get out of the way.

One of the things I have previously found Javascript to lack compared to Matlab, R, Python, or Julia (or Excel for that matter) for doing exploratory data analysis is a standard dead-simple plot tool when you want to draw a bar chart or scatter plot without thinking about it or making any up-front decisions.

Vega-lite (and especially D3) make it possible to make pretty and sophisticated charts with lots of bells and whistles, but I still find vega-lite heavyweight when I want a plot right now. This would surely get easier with experience, but for a newcomer it still adds noticeable friction.