[franklyt]

That’s a huge difference. Do you have a citation for this claim? I don’t doubt you, but, wow.

[inglor_cz]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076378/

Look at the section 4.1. Molecular Stabilization. Yes, it is a challenge, but a challenge that has been overcome.

[hoseja]

You can probably design the fragment so it doesn't mesh well with the recycling apparatus of the human cell but still works for transcription.