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by ortusdux 1886 days ago
prion infections are always eventually fatal, there is no cure, and they are contagious.

The majority of research into prions happens post mortem, and is usually trying to pin down the cause of death. Statistically, there must be prions that are not lethal.

I'm reminded of the issues with people that work at pig processing plants, who had the job of blowing the brains out of the skull cavity with compressed air. Many were not issued proper PPE and ended up with a wide variety of symptoms.

https://www.twincities.com/2008/02/06/minn-to-question-25-mo...

1 comments

I think that's an interesting point. Do you have a source for your statement, that most of the research happens post mortem?

It makes sense to me that non-lethal cases wouldn't be discovered, as it's probably prohibitively expensive to screen for non-lethal/dormant infections. It could also be that the progression is so slow for most people, that they die from unrelated causes before the disease becomes a problem (this is pure conjecture on my part)

The first promising blood test for mad cow (vCJD) was developed in 2016. Prior to that, "The only current method to diagnose vCJD is to perform a biopsy or a postmortem analysis of brain tissue." (NIH 2017).

https://www.nih.gov/news-events/nih-research-matters/new-met...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538786/

Scientists have since developed a promising method that relies on analyzing the retina.

https://www.nih.gov/news-events/news-releases/scientists-ide...

Thank you for the links - I look forward to reading the articles :-)