I've come to find Datomic less than great for prototyping in situations where my data model is evolving. Since your history of data is immutable you get to live with all of your mistakes forever, you can't really just write a migration that shifts from one data model to the next.
It was a service ticket system where we moved from a boolean status to a string for more states (noob modeling mistake I know). The problem came up a few months later when a dev pulled every attribute, saw the old field, and wrote new code against the old field, leading to some really confused tickets.
Looking at that blog post though, it seems that using #9: Annotate your Schema could have helped us avoid this situation. Thats an interesting feature of Datomic I was unaware of.