[rank0]

Psilocybin content varies wildly in street mushrooms. I don't think a comparison between pharmaceutical grade psilocybin and illicit uncontrolled mushrooms is very useful.

I've witnessed lots of people losing their shit after eating an eighth.

[Tenoke]

It's still the same substance. The main difference is that with street mushrooms there's risk the dosage will be much higher, and that risk isn't there with a properly measured dose in a study.

[rank0]

Yep same substance but you misunderstand my point.

The risk here is that street mushrooms usually are going to be LESS potent than people think. What happens now, is that people pull the random statistic out of thin air saying "well 3.5g is about 35mg psilocybin so 25mg is good for the study." In reality, this dosage might end up being much higher than many of the positive anecdotes about "eating an eighth". And again, there's a million horror stories that use that same 3.5g weight.

That's why its silly to compare pharma-grade psilocybin with anecdotal evidence of street mushroom potency.