[benrapscallion]

“Reduce APOE” is an oversimplified view. The mechanisms by which the AD-associated E4 genotype (arg112, arg158) results in disease are still poorly understood. The main therapeutic hypothesis for AD is to reduce the levels of pathogenic plaques and aggregates using antibodies.

[kick_in_the_doo]

Interesting. And these studies have shown that medicine which reduces these plaques doesn't actually help with AD symptoms?