[ryankemper]

The fact that the vaccines create just a single spike protein and the real virus creates much more is actually one of the issues.

First: does the rate at which the cells are made to artificially produce spike protein follow a different curve than the rate at which SARS-2 would? i.e. could mRNA vaccination cause a much more aggressive "inflammatory cliff", thus the huge percentage of "mild" adverse reactions (mild meaning, you feel like death for a day but end up fine with no detectable long-term issues)? It's possible.

And switching to efficacy, while personally I think resistance to the spike protein alone will be sufficient, because SARS-2 does not have the same ability to mutate/evolve the way Influenza does (for example, I can't imagine SARS-2 evolving away from the spike protein), it's very possible that the diverse epitopes produced by real SARS-2 infection give a much more robust and enduring immunity.

[fastball]

Your point about efficacy is not currently born out by the data, AFAIK. Seems like re-infection after COVID is much higher than infection after vaccine.

[ryankemper]

What dataset are you referring to?

[fastball]

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

[ryankemper]

That doesn't compare vaccination to naturalistic rates at all. It just gives rates of reinfection for those with antibodies versus without.