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by laplacesdemon48
1888 days ago
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I want to be perfectly clear that I didn't bring this up to be alarmist. Jesse Gelsinger's death shed a lot of light on the risks involved with adenoviruses [1]. Those lessons have been carried forward. >> An autopsy and subsequent studies indicated that his death was caused by a fulminant immune reaction (with high serum levels of the cytokines interleukin-6 and interleukin-10) to the adenoviral vector. >> The data suggested that the high dose of Ad [adenoviral] vector, delivered by infusion directly to the liver, quickly saturated available receptors ... within that organ and then spilled into the circulatory and other organ systems including the bone marrow, thus inducing the systemic immune response. He was injected with >3 × 10^13 viruses [2]. The typical J&J dose contain: low-dose (5x10^10 viral particles) or high-dose (1x10^11 viral particles) [3]. [1] https://www.uab.edu/ccts/images/steinbrook_Gelsinger_-_Oxfor... [2] https://www.cell.com/molecular-therapy-family/molecular-ther... [3] https://www.jwatch.org/na53085/2021/01/26/adenovirus-vectore... |
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