[ceejayoz]

Being in the nucleus and being integrated into your chromosomes so that they are copied during cell division aren't the same thing.

https://www.medpagetoday.com/special-reports/exclusives/9160...

> Adenoviruses -- even as they occur in nature -- just do not have the capacity to alter DNA. Unlike retroviruses such as HIV or lentiviruses, wild-type adenoviruses do not carry the enzymatic machinery necessary for integration into the host cell's DNA. That's exactly what makes them good vaccine platforms for infectious diseases, according to Coughlan.

> And, engineered adenoviruses used in vaccines have been further crippled by deleting chunks of their genome so that they cannot replicate, further increasing their safety.

[dahfizz]

This sounds a bit like a technicality. The DNA makes it into the cell nucleus and is used by the cell machinery to make proteins. The changes aren't carried over after cell division, but lots of cells in your body last your whole life (nerves, brain cells, eye cells, important stuff).

[ipaddr]

I was under the impression all cells in the body will be regenerated in 7 years.

[laplacesdemon48]

Loss of neurons and cardiac muscle cells is permanent. Emergency medical personnel are usually taught "time is brain" and "time is heart" for this reason.

Some body cells can bounce back after serious trauma, liver cells being a prime example: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701258/