[iso1631]

For a normal NASA flight

"NASA told Business Insider it estimates there’s a 1-in-276 chance the flight could be fatal and a 1-in-60 chance that some problem would cause the mission to fail (but not kill the crew)"

That's fairly low - feels like the age of sail would be far higher -- Columbus's second voyage alone had about 25 deaths just from scurvy. His first voyage was only about 90 crew.

But remember that life wasn't exactly easy on land either.