Just upgraded my side project to both Django 3.2 and Tailwind 2.1 (with Jit enabled). No issues at all, other than some deprecation warnings on some 3rd party packages that will probably be fixed soon.
We use TailwindUI - combined with Django gives a really nice kickstart on new projects. Just made a Proof of Concept last two weeks for an internal business app for a new customer and did impress them easy with a working app + login + responsive nice looking layout. Used VUEjs for menu's, keyboard events and a location picker.
I've used more component-based frameworks like Bootstrap before, but I've found it's easier to have a set of utilities and build my own components on top of that.