I might remove MDMA from that list -- the head researcher at Johns Hopkins for this study was interviewed about a similar 2006 study he did; it mentions that studies at John Hopkins have shown the potential for brain damage from MDMA ("certain nerve cells", anyway).
http://www.hopkinsmedicine.org/Press_releases/2006/Griffiths...
Heh, it's a shame that that myth is still around. The study was actually retracted by the "scientist" himself after he discovered that his lab had administered methamphetamine instead of MDMA.
However, MDMA should certainly not be taken more than a couple of times a year. It's not something you mess around with, we don't know enough about how it affects brain chemistry yet.
> However, MDMA should certainly not be taken more than a couple of times a year. It's not something you mess around with, we don't know enough about how it affects brain chemistry yet.
There are those who find those two sentences a bit curious, and those who do not.
It's interesting how so many people will balk at taking an illegal drug because they "don't want to risk brain damage", and yet will think nothing of driving or riding in a car and risking both brain damage and death nearly every day.
Mountain climbing, rock climbing, skydiving, scuba diving, and even just walking across the street all risk serious bodily injury, brain injury, and death. Yet most people won't freak out if you choose to engage in one of these activities.
But if you dare to swallow a pill every now and then, you're treated as a reckless, immoral madman.
It's because people understand what can go wrong and how it goes wrong in all of the activities you listed above. However I'll wager that many illegal drug users don't know what goes on at all and have no clue what can go wrong. Even when they do, I think it's pretty smart to acknowledge that brain chemistry is far more complicated than car crashes, and it's harder to figure out the unexpected / long term effects of one than the other.
Brain damage from any of the activities I listed above (including car crashes) could manifest itself in any number of ways. And it's impossible to tell ahead of time what the long-term effects of such brain damage will be.
I'm not really sure that knowledge of what can go wrong explains much about the different attitudes society at large has towards drug users vs people who engage in other risky activities (including simply riding in a car).
Most people know that if you ride in a car you could get in to a car accident and you could be maimed or killed or wind up a vegetable. How does knowing these potential effects explain the differing attitudes towards car drivers vs drug users?
That's a pretty weak argument. We know that there are certain situations in those sports that can cause brain damage, like getting hit on the head by a rock and lack of oxygen. We know them fairly well, and the majority of people avoid them successfully.
With rock climbing or driving or scuba diving, it's an "It might happen to you, but if you avoid these extreme situations it won't" situation whereas with taking drugs you can't really avoid pitfalls, other than taking care not to take too large a dose.
With drugs it's likelier to be "you get smaller amounts of damage if you take smaller doses" or plain "we don't know what the fuck this thing does".
I agree that it doesn't explain much about the attitudes. The default attitude should be ambivalent until we know more, not hostile.
It should be noted that there was a scandal involving MDMA research at Johns Hopkins. A study claimed to prove that MDMA caused brain damage, but in fact Methamphetamine had accidentally been administered instead of MDMA.
http://www.wired.com/techbiz/media/news/2003/09/60328
Of course, this doesn't disprove other legitimate studies. The interview you link took place well after that scandal.
I was unaware that the research had been discredited; thanks for letting me know.
That said, for those who are interested, here is the paper that the article is referring to:
Griffiths, R.R., Johnson, M.W., Richards, W.A., Richards, B.D., McCann, U., & Jesse, R. (in press). Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects. Psychopharmacology.
... and here is the previous study he did:
Griffiths, R.R., Richards, W.A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187, 268-283.
MDMA is much more potentially dangerous than those other drugs, especially in an acute way. The "safety factor" (ratio between dangerous dose to useful dose) is huge for THC, LSD, mushrooms, DMT, K, etc., and much smaller for MDMA, Meth, K, opiates, coke.
There are a few (DOB?) which have safety factors around 2-4x, which is really unsafe.
erowid.org is probably a much better source of info on this topic than hacker news, though.
http://en.wikipedia.org/wiki/Retracted_article_on_toxicity_o...
However, MDMA should certainly not be taken more than a couple of times a year. It's not something you mess around with, we don't know enough about how it affects brain chemistry yet.