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by _Gyan_ 1910 days ago
The primary endpoint is symptomatic infection, not any infection per se. And it's a bit of a kludge, as all the Phase III protocols I've read define symptomatic infection as X no. of symptoms for Y+ no. of days i.e. there are people with fewer symptoms who aren't counted (or even tested to check for infection).

The efficacy is the 1-relative risk of the primary endpoint.