I have found that I am involved with too many things with too many random people for that to work, so instead I flip my phone to silent mode whenever I am doing something interesting or with people, and then if somebody notify when when I am browsing hn, that is probably fine.
I have DND on during the night and work day. Like gp, if somebody can make it sound at 4 A.M, I want to be there to take the call, but it is almost certainly bad news.
I do something similar but have my DND hours for my work apps set on outside work hours and at night. If someone really needs me, they can call me twice in a row to override the DND and sound my ringtone (at least on iOS).
I have DND on during the night and work day. Like gp, if somebody can make it sound at 4 A.M, I want to be there to take the call, but it is almost certainly bad news.