[emiliobumachar]

I have no knowledge beyond what I just heard from you.

That sounded implausible. The country which had the ability to negotiate that happened to be the same country where the doses were manufactured? Why couldn't the UK apply its careful negotiating skills elsewhere too?

Alternative hypothesis: the credible implicit or explicit threats of a ban were what enabled the deal. "Sign this or else."

[cameronh90]

The UK government provided a lot of the money to AZ to build out the local vaccine supply chain and factories. Those factories most likely wouldn't exist unless the UK government had paid that money. So, as part of paying for all that, they asked for timed exclusively.

Also remember the vaccine was developed by Oxford using a significant amount of UK government funding, and was licensed to other countries, such as India, for low cost manufacturing.

We did also buy a lot of vaccine from other places (e.g. Pfizer which is also being widely deployed). But with AZ in particular (and to some extent Novavax) there was a focus on building a local supply chain so that countries can't play games with our vaccine supply. Supposedly Pfizer turned down the offer to build UK based factories.

[mpweiher]

> The UK government provided a lot of the money to AZ to build out the local vaccine supply chain and factories

So did the EU.

> Also remember the vaccine was developed by Oxford using a significant amount of UK government funding

And Biontech was developed with German funding. Did Germany insist on exclusivity? Maybe we should have...

[vanilla-almond]

- The vaccine is mainly funded by Oxford University and AstraZeneca (AZ) . The UK Government also provided £65.5m.

- Most of the AZ vaccine for the UK is being made in the UK. AZ have said none of their vaccines have been sent from the EU to the UK.

- AstraZeneca said its agreement with the EU allowed the option of supplying Europe from UK sites, but only once the UK had sufficient supplies (due to the contract the UK negotiated) .

- A drop in confidence in the AZ vaccine means there are lots of unused vaccines. France and Germany have used only about half of the AstraZeneca jabs they have received, according to the European Centre for Disease Prevention and Control (ECDC).

- 10 million Pfizer-BioNTech vaccines have been exported from the EU to the UK.

Sources:

https://www.bbc.co.uk/news/56483766

https://www.politico.eu/article/the-key-differences-between-...

[mavhc]

Are there really a lot of unused vaccines in Europe though? What are the equivalent numbers for other countries? I submit it's a supply chain thing, there's a week's worth of vaccines moving from the factory to the humans

[helij]

No there are not. Those are second doses. In EU they 'reserved' second doses. UK for example went on to vaccinate as much as possible. That's why there will be a delay now of a month or two.

[mpweiher]

> France and Germany have used only about half of the AstraZeneca jabs they have received

Now why might they have only used half so far, of a vaccine requiring two jabs?

They are keeping the other half for the required 2nd jab.

For some bizarre reason, they are not confident about timely delivery of future supplies.

[inglor_cz]

Unfortunately the drop in consumer trust has been enormous. [0] And humans lose trust faster than they regain it.

After the wild "let us suspend AZ and let us restart it in two days" ride, it will be much harder to get AZ into arms of European patients. Even here in the Czech Republic, where AZ wasn't suspended, the reverbations in the public are stark and all kinds of half-baked conspiracies started circulating. (An example: "Germans want to get rid of a junk vaccine and force it on us Slavic untermenschen, while they will only use more expensive and better Pfizer for themselves.")

[0] https://yougov.co.uk/topics/international/articles-reports/2...

[mpweiher]

(a) Consumer confidence wasn't high in the first place

(b) This wasn't without reason. AZ has significantly more severe side effects and is less effective.

(c) That said, I'd certainly still take it, it is highly effective at preventing the worst outcomes.

(d) That said, the whole "consumer confidence" narrative is a canard. Its effects don't come anywhere near the effect of the delivery shortfalls. It's so totally ridiculous that it does make me wonder where it is coming from.

[jackdh]

> So did the EU.

How much did they fund before the initial order? I can't seem to find a source. All the results just talk about their down payment not the initial funding like the UKs £65m. https://www.bbc.co.uk/news/56483766

[mjcl]

Another hypothesis: Oxford was originally going to partner with Merck [1] but there were no supply guarantees in that contract. AstraZeneca was willing to give guarantees and run production in the UK, so the UK government leaned on Oxford and had them partner with the more agreeable supplier.

[1] https://news.sky.com/story/covid-19-rejected-contracts-and-a...

[_benedict]

I don’t know why you presuppose the U.K. is where it would have had to be manufactured. Manufacture in the U.K. appears to have been made to happen at the insistence and investment of the U.K. government, from my recollection of a thread by an Oxford researcher involved.

There appears to be a similar deal with Novavax to setup similar domestic capacity in the UK for its vaccine.

[petr_tik]

Even if the UK was threatening AZ with an export ban, they didn’t force AZ to accept those terms. AZ could have just said no and made the U.K. government look incompetent and unleashed media scrutiny on BoJo.

Yes, having the industrial base is part of the attraction of the UK for pharmaceutical companies. As is having a skilled workforce and a reliable system of laws.

I’m rejecting your original point about the U.S. and U.K. doing the same thing, which they aren’t.

[aktuel]

Well, the motivation and effect is exactly the same which is what most people care about in the end. It's a nationalistic move which is what makes your day if you're a nationalist.