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by ghgdynb1 1924 days ago
1: Agreed.

2: One of the problems a lot of people see barring the use of bacteriophage therapy for combating bacterial infection in the clinic is the really fine specificity of most phages to their hosts. The skeptics will suggest that you'd need to essentially design a new phage therapy for each individual infection.

With the advances we're seeing in microfluidics, diagnostics, gene sequencing, computational biology, laboratory automation, and the theory of precision medicine, that host specificity can turn from a disadvantage to an advantage. We know there are a lot of human-dwelling bacteria we wouldn't want to knock but can't save from a broad-spectrum treatment. With a personalized phage therapy, this isn't as much of a concern.