[arp242]

A desktop computer is not a mobile device though; there are different sensibilities involved because pretty much everything is different. A lot of UX regressions from the last years come from this mistake.

What is more "natural" is a pointless discussion anyway IMO; I regret phrasing it like that and I wish I could edit it. As I said, the key is to put things where people's eyes and mouse cursor will go, and that's rarely a "jump" to an entirely different place on the screen (on mobile this problem exists less because the screens are small). While it doesn't matter too much on narrow forms (less of a jump), on wide forms it's a bigger issue (or if it's placed to the right of the form inputs take).

[fakedang]

Having been conditioned on Windows since my childhood (like nearly every person out there), I would be very weirded out if the Submit button was on the left on a desktop.

[godshatter]

Whichever is chosen, just make it visually distinct from the other buttons, and be consistent, and I'll be content (if not actually happy, depending on which one matches my opinion).