[p00dles]

I removed the F1 from a keyboard so that I don't misfire when going for F2, resulting in the dreaded 'Help' window that you have to use a mouse to click out of.

[layer8]

Ctrl+Space, C used to work for closing the Help window until recent versions. Unfortunately that doesn’t work anymore, the only solution is to use a VBA macro bound to a keyboard shortcut. At least in return the keyboard focus now remains in Excel instead of switching to the Help dialog.

[aksss]

Microsoft PowerToys on Win10 will let you remap keys. If nothing else you could make F1 do what F2 does.

https://docs.microsoft.com/en-us/windows/powertoys/