Cosmopolitan Libc: build-once run-anywhere C library - https://news.ycombinator.com/item?id=25556286 - Dec 2020 (166 comments)
and the current related thread is still high on the front page—long may it reign:
Show HN: Redbean – Single-file distributable web server - https://news.ycombinator.com/item?id=26271117 - Feb 2021 (182 comments)
There are also these related threads:
Actually Portable Executable - https://news.ycombinator.com/item?id=26273960 - Feb 2021 (133 comments)
αcτµαlly pδrταblε εxεcµταblε - https://news.ycombinator.com/item?id=24256883 - Aug 2020 (286 comments)
How Fat Does a Fat Binary Need to Be? - https://news.ycombinator.com/item?id=26103769 - Feb 2021 (68 comments)
Others?