[TheBlerch]

Congratulations Aakash and Manan on your launch! Talk about addressing an actual, physical pain point. Best of luck unstuffing the nation. A few questions: 1) How many months treatment time is necessary to see recognizable results? 2) How soon after starting Wyndly treatment can users stop using antihistamines such as anti-histamine pills and inhalers? 3) Generally how long must treatment be maintained before it can be stopped, and how long will the results last? A European poster in this thread mentioned his dust mite allergy requires 3 years of drops before they can be stopped for 3 years, after which the treatment must be repeated.

[ahstilde]

Thank you!

Patients see improvement in symptoms after 6 months, with some patients reporting improvement as soon as 6 weeks. For most patients, this means they can stop taking their antihistamines.

You mentioned inhalers. While there has been connection between allergy immunotherapy and asthma, allergy immunotherapy is not a replacement for your asthma inhaler.

If a patient stays on drops for 5 years, they can expect decades of allergy relief after they stop the drops. If the patient stops taking their allergy drops earlier, they will still see a reduction of their allergy symptoms, but it won't last for decades -- it may only last a few months, depending on how long they took the drops.

I just saw the European poster. I don't have the details of his treatment, so I can't address why they had to repeat their treatment. For our patients, the goal is lifelong allergy relief as easily as possible. We don't want you to have to repeat your treatment. If you never talk to us after your treatment, that means we did something right.

[billh]

Do you have a patient transition plan in place in the unfortunate case of Wyndly dissolving or a contingency for continual treatment for the duration of the 5 years?

It seems that it would be rather difficult for a patient to transition to another providers care on their own given how few doctors are working with SLIT.

[ahstilde]

We partner with physicians and pharmacies to provide SLIT. If anything was to happen to Wyndly, we'd transition patients directly to these physicians and pharmacies and make sure the patient experience was as seamless as possible.

It's incredibly important to us that our patient experience is as easy and seamless as possible. We'd bring this same philosophy to any transition.

[TheBlerch]

Thank you for the info, which I'll gladly share with friends and family that are sufferers. What determines when the user has achieved relief and can stop the drops treatment? What data or tests allows Wyndly to know if a user has achieved relief in 2, 3 or 5 years?

[ahstilde]

Patients experience relief when they no longer have allergy symptoms.

Here are some research papers you can share:

Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study https://pubmed.ncbi.nlm.nih.gov/20934206/

Efficacy and Safety of Subcutaneous and Sublingual Immunotherapy for Allergic Rhinoconjunctivitis and Asthma https://pubmed.ncbi.nlm.nih.gov/28964530/

Clinical improvement after escalation for sublingual immunotherapy (SLIT) https://pubmed.ncbi.nlm.nih.gov/21938688/