[eivarv]

That's not my experience, at least. I haven't had any major issues I wasn't able to solve with either.

Even if I were more comfortable with web tech when I first started experimenting with this stuff (some time around 2012-2015) I still found the end result much better.

[Neputys]

If you don't go beyond standard interactions and look it's probably fine but let's say I want system chrome to look like the one in photoshop and some custom dropdowns for starters...

[ianlevesque]

Why would your desktop users want your weird drop downs? UI consistency used to be a thing.

[kaszanka]

Some companies/people take branding too seriously.

[jcelerier]

... it'd be doable ? E.g. look at telegram which is a Qt app and even more foreign-looking than Photoshop: https://images.app.goo.gl/JVNR4Jetmh7frvwo6 . Or allegorithmic substance, also made in Qt: https://images.app.goo.gl/CbJaGhRvSswymAjQ7