[hderms]

Yeah it would increase the conditionality or contextuality of any given observation because even if the genomes were identical, you have differing levels of gene expression based on environmental stimuli.

So observing that gene X impacts biochemical pathway in some way Y is already really difficult when there are tons of other genes at play. Add on the fact that these genes could be triggered to stop expressing themselves in certain conditions and it makes the whole process of figuring out what is really going on that much more difficult. Even if we can make some observation, there are tons of contextual situations which would potentially invalidate that observation.