[marsdentech]

This is a common, and often justified, though not always fair, criticism. MinIONs have an error rate of around 10% for _any given base_. Moreover, these errors aren't entirely independent of one another, so if you struggle to sequence a given base the first time, you're likely also to struggle if you try again. That said, if your experiment is such that you're only sequencing a guaranteed single target (e.g. one, isolated coronavirus genome), in that one sequencing run (on that one flow cell), you'll "re-sequence" the same any given region many times and, unless you're looking at "problematic" (i.e. low-complexity) regions, you _will_ be able to "average out" the errors to reveal the true target sequence. On the other hand, if you're trying to co-sequence a mixture of closely-related targets, that's when the headache starts...