Work from home for people living by themselves away from family (separated by countries) gets depressing and will most likely impact productivity at work.
While I fit the profile you mention...After 20 years WFH, I can't say I find it depressing. YMMV, but I think its how you do it. The lockdowns have probably made WFH seem a lot more isolating (no working from hacker spaces, coffe shops, etc.)