[naikrovek]

If the pollution is severe enough to KILL the species creating it, it is already being produced far faster than nature can absorb it or counteract it. It also seems feasible that other species are killed as well; species which may have helped clean the pollution from the planet, which would slow the cleaning process or, if enough species die off, stopping the cleansing process almost entirely.

Pollution doesn't vanish when it isn't being made anymore.

So, if there is so much pollution that it both kills life on the planet, it will take a good amount of time (millions of years? How big of a planet are we talking about?) to be cleansed back to undetectable levels.

[GoblinSlayer]

So far volcanic eruptions were the most dangerous for life.