[cryptoquick]

Do refrigerated semis use more fuel? And if so, by what factor more?

[s1artibartfast]

no clue. your google guess is as good as mine

Edit: got curious and spent 2 minutes to do the google. The unvetted answer is aprox. 10%

A semi can run ~1500 mi on 200 gallons @7.5 mi/gallon and a trailer refrigerator uses about 10 gallons/day