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by wittyreference 1980 days ago
I came up with the same idea for treating autoimmune disease years ago - in my first year of med school, actually. Back then the platform for doing this elegantly via mRNA didn't really exist, though, and I didn't want to drop out of med school to spend a half-decade or more in grad school proving the concept the clumsy way.

I'm really glad that it's finally come to fruition, but I definitely feel a bit of regret that I have come to embody the "ideas are cheap, execution matters" truism.

4 comments

Don't feel too bad, the execution depended on a massive world-changing pandemic where funding flowed freely and normal economics just didn't apply.
They were working on applying mRNA technology to other diseases, including (and in particular) cancer, well before the pandemic. While it is true that they have received significant funding this year, they had a $7.6B market cap on Dec 31, 2019 and were already conducting several clinical studies for mRNA-based medicine [1].

[1] https://web.archive.org/web/20200128054759/https://biontech....

Smaller companies here in the bay area as well, see: Rejuvenation Tech.
Moderna is too.
IMO, the healthier coping mechanism is to realize that the path you take in life will never be the most optimal. We all make mistakes, and if all we care about is extrinsic achievement, we'll be either steeped in regret (or perhaps, blissfully ignorant). Instead of being outcome dependent, try to value things that are by nature, intrinsic.
No. The cash helped develop a vaccine this fast, but further application comes with the recent innovation in the lipid nano particles for delivery. That was done before the pandemic.
Not to worry! When I was a little kid, I couldn't afford new shiny magazines,so I had an idea of an online library hosting all the magazines for a small monthly fee. Guess what, turns out apps like Readly doing exactly that.
We don’t even know if this will work so I wouldn’t feel too bad.
Please provide a link to your thesis.