| https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/ > Of 50 patients treated with calcifediol, one required admission to the ICU (2%), while of 26 untreated patients, 13 required admission (50 %) p value X2 Fischer test p < 0.001. Strengths: Randomized, very strong effect, strongly statistically significant. Weaknesses: single trial, single center, relatively small sample, not blinded. https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-20... > Greater proportion of vitamin D-deficient individuals with SARS-CoV-2 infection turned SARS-CoV-2 RNA negative with a significant decrease in fibrinogen on high-dose cholecalciferol supplementation. Strengths: Randomized, blinded trial Weaknesses: single trial, single center, relatively small sample, secondary outcome measure |