for what it's worth I've got a Pi-Hole running on my local network instead of in-browser adblock, and it's pretty good, and before that i had some success with 1Blocker, which IIRC uses the same lists as uBlock Origin.
YMMV (probably depends on the subset of the web that one visits) but I've had good luck with Wipr under Safari. Once in a while something slips through but it's generally ~99% as effective as uBO when it comes to visible ads. The difference is small enough that I'm not inclined to use a different browser.